Ibuprofen can cause male infertility

Researchers looked at 31 male participants and found that taking ibuprofen reduced production of testosterone by almost a quarter in the space of around six weeks. Unfortunately, a new study says that ibuprofen can actually reduce fertility rates in men.

The long-term use of ibuprofen, a widely used over-the-counter painkiller, carries the risk of repressing a testicular hormone and reducing libido and male fertility, scientists have said. And now, new research shows that it can cause infertility, erectile dysfunction, muscle atrophy and fatigue in men.

The decreased ratio of testosterone to LH created a hormonal imbalance called "compensated hypogonadism" in the endocrine system, which regulates and controls hormones.

So researchers wanted to look into what happened in adult males who took ibuprofen, which had the strongest results in the earlier study.

The research focused on men given 600mg of ibuprofen twice a day, which isn't the norm for the average bloke.

Common brands of ibuprofen include Advil and Motrin.

The disorder normally occurs when the testes do not produce enough testosterone, so the body boosts production levels of the hormone. Some took 1,200 milligrams of ibuprofen daily, which is the maximum limit as directed, over a six-week period.

The finding comes after repeated warnings from other researchers that ibuprofen can raise the risk of heart attacks in the general population and cause medical problems for pregnant women and their babies, including a more than doubling of the risk of miscarriage. This repression results in the elevation of the stimulatory pituitary hormones, resulting in a state of compensated hypogonadism, a disorder associated with adverse reproductive and physical health disorders. The 17 other volunteers were given a placebo pill.

While "it is sure" that the hormonal effects in the study participants who used ibuprofen for only a short time are reversible, it's unknown whether this is true after long-term ibuprofen use, study co-author Bernard Jegou, director of the Institute of Research in Environmental and Occupational Health in France, told CNN. The effect was apparent at two weeks and became more pronounced after six weeks of ibuprofen use. "Ibuprofen is a very useful drug for acute pain conditions, its benefits have been well proven, but it is important to consider that hypogonadism may be an additional risk factor that people need to watch for when taking the drug for a long time", he said.

  • Delores Daniels